![]() ![]() Excessive administration of single-dose aspirin, as well as long-term, can cause the risk of poisoning. However, the dose of aspirin used as an antiplatelet drug in clinical trials is not equivalent. Aspirin (Acetylsalicylic acid-ASA) works by inhibiting the synthesis of thromboxane A2 (TXA2) in platelets and prostacyclin (PGI2) in blood vessels by irreversibly inhibiting cyclo-oxygenase enzymes. This antiplatelet therapy is said to be effective in treating severe vascular disease with both short-term and long-term administration. Cardiovascular disease (CVD) has been the leading cause of death in Indonesia, which is about 37% of all deaths (1,551,000) in the country.Īdministration of antiplatelet drugs such as aspirin can reduce mortality caused by CVD. Īccording to WHO-Noncommunicable Diseases (NCD), Country Profiles in 2014. In the Asia / Pacific region, the main cause of death is CVD, which is estimated at 9.3 million deaths and accounts for about a third of all deaths in 2012. The main cause of NCD death in 2012 is cardiovascular disease (CVD) that is as many as 17.5 million deaths, or 46% of all deaths due to NCD. Deaths caused by noncommunicable diseases (NCDs) account for 38 million of the 56 million global deaths, which is about 68%. According to the World Health Organization (WHO) in 2012. The underlying pathology of CVD is atherosclerosis. Ĭardiovascular disease (CVD) is the leading cause of disability and premature death worldwide. ![]() For example, in patients with transient ischemic attacks (TIAs), cerebrovascular disease (stroke), myocardial infarction or peripheral artery blockage are classified as cardiovascular disease (CVD). In other words, thrombosis is the formation of a pathological hemostatic plugin blood vessels that do not bleed. The process of hemostasis can occur without any additional injury to the blood vessels of patients with a history of heart disease and abnormalities in blood vessels. ![]() Three major mechanisms that occur to reduce blood loss are vascular spasm, platelet plug formation, and coagulation (blood clotting). ![]() When blood vessels are damaged or broken, then the hemostasis process must occur quickly in areas that have been damaged and carefully controlled to be effective. Hemostasis is a body reaction that occurs sequentially to stop the bleeding. ![]()
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